PlA2, a variant of GPIIIa implicated in coronary thromboembolic complications.

Ischemic heart disease (IHD) and adverse events after coronary stent placement represent polygenic disorders. They correspond to complex traits induced not only by multiple genes but also by the interaction of these genes with the environment. Multiple loci likely to be implicated in IHD are polymorphic, such that there are two or more variant forms of the gene in the population. These variants have been created by mutations that can change the coding sequence of the gene in question. A missense mutation, for example, would produce a different form of the encoded protein, whose function might be slightly altered compared